Contact

Dr. Tobias L. Lenz
Dr. Tobias L. Lenz
Research Group Leader
Phone: + 49 4522 763-228
Fax: +49 4522 763-310
Room: PinkR

Selected recent publications

Pierini F Lenz TL

Divergent allele advantage at human MHC genes: signatures of past and ongoing selection

Krause-Kyora B, Nutsua M, Böhme L, Pierini F, Pedersen DD, Kornell S-C, Drichel D, Bonazzi M, Möbus L, Tarp P, Susat J, Bosse E, Willburger B, Schmidt AH, Sauter J, Franke A, Wittig M, Calibe A, Nothnagel M, Schreiber S, Boldsen J*, Lenz TL*, Nebel A*

Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

Lenz TL

Adaptive value of novel MHC immune gene variants [Invited Commentary]

Emmy Noether Group Evolutionary Immunogenomics (Lenz)

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Emmy Noether Group Evolutionary Immunogenomics

The coevolution between hosts and parasites is increasingly being recognized as one of the major drivers for the evolution of genetic diversity. We are interested in the evolutionary forces and constraints that shape the functional diversity of the vertebrate immune system, from the sequence level to genomic organisation and protein structure. Our research is strongly based on computational analysis of genomic and epidemiological data from human populations, but includes also molecular and experimental approaches using the three-spined stickleback and other model species. Current projects range from the genomic organisation of the major histocompatibility complex (MHC) in both sticklebacks and humans to immunogenetic selection in human populations and an evolutionary perspective on the association between human leukocyte antigen (HLA) diversity and autoimmunity.

Our research group is supported by the Emmy Noether Programme of the German Research Foundation (DFG).

 
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