Contact

profile_image
Dr. Tobias L. Lenz
Research Group Leader
Phone:+49 4522 763-228Fax:+49 4522 763-310
Email:lenz@...

Recent publications

Lenz TL, Spirin V, Jordan DM, Sunyaev, SR

Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection

Savova V, Chun SG, Sohail M, McCole R, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA

Genes with monoallelic expression contribute disproportionately to genetic diversity in humans

Lenz TL*, Deutsch AJ*, Han B, Hu X, Okada Y, ... [29 co-authors] ..., Sunyaev SR, de Bakker PIW, Raychaudhuri S

Widespread non-additive and interaction effects within the HLA modulate the risk of autoimmune diseases

Emmy Noether Group Evolutionary Immunogenomics

Evolutionary Immunogenomics

The coevolution between hosts and parasites is increasingly being recognized as one of the major drivers for the evolution of genetic diversity. We are interested in the evolutionary forces and constraints that shape the functional diversity of the vertebrate immune system, from the sequence level to genomic organisation and protein structure. Our research is strongly based on computational analysis of genomic and epidemiological data from human populations, but includes also molecular and experimental approaches using the three-spined stickleback and other model species. Current projects range from the genomic organisation of the major histocompatibility complex (MHC) in both sticklebacks and humans to immunogenetic selection in human populations and an evolutionary perspective on the association between human leukocyte antigen (HLA) diversity and autoimmunity.

Our research group is supported by the Emmy Noether Programme of the German Research Foundation (DFG) and the Alexander v. Humboldt Foundation.

 
loading content