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Seminar series on Mathematical Evolutionary Biology - Pleuni Pennings: The evolution of HIV drug resistance evolution from the 1980s until now

  • Date: Nov 20, 2018
  • Time: 11:00 - 12:00
  • Speaker: Pleuni Pennings from the San Francisco State University, CA, USA
  • For more information on Pleuni Pennings, please check: http://biology.sfsu.edu/people/pleuni-pennings
  • Location: MPI Plön
  • Room: Lecture hall
  • Host: Linda Odenthal-Hesse & Chaitanya S. Gokhale

Abstract
Drug resistance evolution was a huge problem for HIV treatment from the late 80s all the way until a a few years ago. It is often suggested that the way to prevent drug resistance evolution is to use at least three drugs at the same time. I will use historical data to show that it is more complicated. The initial three-drug therapies for HIV still allowed for drug resistance evolution to happen. I will propose a hypothesis that can explain why newer triple-drug therapies work much better – we believe that it is related to spatial structure of drug and virus in the human body.


 
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