Publikationen

Radwan, J.; Babik, W.; Kaufman, J.; Lenz, T. L.; Winternitz, J.: Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics 36 (4), S. 298 - 311 (2020)

Arora, J.; Pierini, F.; McLaren, P. J.; Carrington, M.; Fellay, J.; Lenz, T. L.: HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation. Molecular Biology and Evolution 37 (3), S. 639 - 650 (2020)

Huang, Y.; Feulner, P. G. D.; Eizaguirre, C.; Lenz, T. L.; Bornberg-Bauer, E.; Milinski, M.; Reusch, T. B. H.; Chain, F. J. J.: Genome-wide genotype-expression relationships reveal both copy number and single nucleotide differentiation contribute to differential gene expression between stickleback ecotypes. Genome Biology and Evolution 11 (8), S. 2344 - 2359 (2019)

Degenhardt, F.; Wendorff, M.; Wittig, M.; Ellinghaus, E.; Datta, L. W.; Schembri, J.; Ng, S. C.; Rosati, E.; Hübenthal, M.; Ellinghaus, D. et al.; Jung, E. S.; Lieb, W.; Abedian, S.; Malekzadeh, R.; Cheon, J. H.; Ellul, P.; Sood, A.; Midha, V.; Bk, T.; Wong, S. H.; Schreiber, S.; Yamazaki, K.; Kubo, M.; Boucher, G.; Rioux, J.; Lenz, T. L.; Brant, S. R.; Franke, A.: Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles. Human Molecular Genetics 28 (12), S. 2078 - 2092 (2019)

Arora, J.; McLaren, P. J.; Chaturvedi, N.; Carrington, M.; Fellay, J.; Lenz, T. L.: HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. Proceedings of the National Academy of Sciences of the United States of America 116 (3), S. 944 - 949 (2019)

Chowell, D.; Krishna, C.; Pierini, F.; Makarov, V.; Rizvi, N. A.; Kuo, F.; Morris, L. G. T.; Riaz, N.; Lenz, T. L.; Chan, T. A.: Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine 25 (11), S. 1715 - 1720 (2019)

Hasan Ali, O.; Berner, F.; Bomze, D.; Fässler, M.; Diem, S.; Cozzio, A.; Jörger, M.; Früh, M.; Driessen, C.; Lenz, T. L. et al.; Flatz, L.: Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors. European Journal of Cancer 107, S. 8 - 14 (2019)

Manczinger, M.; Boross, G.; Kemény, L.; Müller, V.; Lenz, T. L.; Papp, B.; Pál, C.: Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations. PLoS Biology 17 (1), e3000131 (2019)

Lenz, T. L.; Hafer, N.; Samonte, I. E.; Yeates, S. E.; Milinski, M.: Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes. Evolution 72 (11), S. 2478 - 2490 (2018)

Pierini, F.; Lenz, T. L.: Divergent allele advantage at human MHC Genes: signatures of past and ongoing selection. Molecular Biology and Evolution 35 (9), S. 2145 - 2158 (2018)

Lenz, T. L.: Adaptive value of novel MHC immune gene variants. Proceedings of the National Academy of Sciences of the United States of America 115 (7), S. 1414 - 1416 (2018)

Krause-Kyora, B.; Nutsua, M.; Boehme, L.; Pierini, F.; Pedersen, D. D.; Kornell, S.-C.; Drichel, D.; Bonazzi, M.; Möbus, L.; Tarp, P. et al.; Susat, J.; Bosse, E.; Willburger, B.; Schmidt, A. H.; Sauter, J.; Franke, A.; Wittig, M.; Caliebe, A.; Nothnagel, M.; Schreiber, S.; Boldsen, J. L.; Lenz, T. L.; Nebel, A.: Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans. Nature Communications 9, 1569 (2018)

Calvignac-Spencer, S.; Lenz, T. L.: The one past health workshop: connecting ancient DNA and zoonosis research. Bioessays 39 (7), 1700075 (2017)

Kaufmann, J.; Lenz, T. L.; Kalbe, M.; Milinski, M.; Eizaguirre, C.: A field reciprocal transplant experiment reveals asymmetric costs of migration between lake and river ecotypes of three-spined sticklebacks (Gasterosteus aculeatus). Journal of Evolutionary Biology 30 (5), S. 938 - 950 (2017)

Lenz, T. L.; Spirin, V.; Jordan, D. M.; Sunyaev, S. R.: Excess of deleterious mutations around HLA genes reveals evolutionary cost of balancing selection. Molecular Biology and Evolution 33 (10), S. 2765 - 2766 (2016)

Huang, Y.; Chain, F. J. J.; Panchal, M.; Eizaguirre, C.; Kalbe, M.; Lenz, T. L.; Samonte, I. E.; Stoll, M.; Bornberg-Bauer, E.; Reusch, T. B. H. et al.; Milinski, M.; Feulner, P. G. D.: Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks. Molecular Ecology 25 (4), S. 943 - 958 (2016)

Savova, V.; Chun, S.; Sohail, M.; McCole, R. B.; Witwicki, R.; Gai, L.; Lenz, T. L.; Wu, C.-t.; Sunyaev, S. R.; Gimelbrant, A. A.: Genes with monoallelic expression contribute disproportionately to genetic diversity in humans. Nature Genetics, 3493 (2016)

McLaren, P. J.; Coulonges, C.; Bartha, I.; Lenz, T. L.; Deutsch, A. J.; Bashirova, A.; Buchbinder, S.; Carrington, M. N.; Cossarizza, A.; Dalmau, J. et al.; Luca, A. D.; Goedert, J. J.; Gurdasani, D.; Haas, D. W.; Herbeck, J. T.; Johnson, E. O.; Kirk, G. D.; Lambotte, O.; Luo, M.; Mallal, S.; van Manen, D.; Martinez-Picado, J.; Meyer, L.; Miro, J. M.; Mullins, J. I.; Obel, N.; Poli, G.; Sandhu, M. S.; Schuitemaker, H.; Shea, P. R.; Theodorou, I.; Walker, B. D.; Weintrob, A. C.; Winkler, C. A.; Wolinsky, S. M.; Raychaudhuri, S.; Goldstein, D. B.; Telenti, A.; de Bakker, P. I. W.; Zagury, J.-F.; Fellay, J.: Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load. Proceedings of the National Academy of Sciences of the United States of America (2015)

Lenz, T. L.: Transcription in space – environmental vs. genetic effects on differential immune gene expression. Molecular Ecology 24 (18), S. 4583 - 4585 (2015)

Lenz, T. L.; Deutsch, A. J.; Han, B.; Hu, X.; Okada, Y.; Eyre, S.; Knapp, M.; Zhernakova, A.; Huizinga, T. W. J.; Abecasis, G. et al.; Becker, J.; Boeckxstaens, G. E.; Chen, W.-M.; Franke, A.; Gladman, D. D.; Gockel, I.; Gutierrez-Achury, J.; Martin, J.; Nair, R. P.; Nöthen, M. M.; Onengut-Gumuscu, S.; Rahman, P.; Rantapää-Dahlqvist, S.; Stuart, P. E.; Tsoi, L. C.; van Heel, D. A.; Worthington, J.; Wouters, M. M.; Klareskog, L.; Elder, J. T.; Gregersen, P. K.; Schumacher, J.; Rich, S. S.; Wijmenga, C.; Sunyaev, S. R.; de Bakker, P. I. W.; Raychaudhuri, S.: Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases. Nature Genetics 47 (9), S. 1085 - 1090 (2015)