Genes for speciation
December 09, 2014
The distribution of the house mouse subspecies cuts across Central Europe: Mus musculus musculus lives to the east, Mus musculus domesticus to west. In the border region, the two sub-species mix.[less]
The distribution of the house mouse subspecies cuts across Central Europe: Mus musculus musculus lives to the east, Mus musculus domesticus to west. In the border region, the two sub-species mix.
Biological science has proposed a number of different species concepts. One thing is certain though: evolution is an ongoing process, and we only observe a brief snapshot of it. A species that exists today can soon split into two subtypes. The process of speciation is particularly easy to study in emerging species: Before the flow of genes is completely interrupted, hybrids are often produced that are viable but are largely or fully infertile.
Male fertility is often related to testicular weight and size. Changes in gene regulation in the testicles can also lead to infertility. Bettina Harr and Leslie Turner of the Max Planck Institute for Evolutionary Biology therefore looked for regions in the genotype of mice that affect testicular weight and testicular gene activity. To this end, they studied normal and partially sterile hybrid mice in a genome-wide association analysis. “The study shows that many different gene regions play a role in the fertility of hybrid males, some of which have never previously been associated with fertility,” explains Turner.
Once the researchers had identified specific areas in the genome, they looked for interactions between them. Many theories suggest that impaired fertility in hybrids is due to interactions between the genes originating from the different subspecies forms. “With one exception, all the loci we identified interact with at least one other region. Most have multiple interaction partners,” says Bettina Harr.
Hence, an intricate web of interactions exists that reduces the reproductive capacity of hybrid mice within the hybrid zone. It is not yet clear precisely which genes lead to altered gene activity or testicular size, but the Max Planck scientists have already made progress in narrowing down the search. Some of the genome sections identified contain fewer than ten genes and therefore present some promising candidates.