Exploring T-cell repertoire diversity in natural populations
This project investigates evolutionary dynamics of the individual T-cell repertoire in the tree-spined stickleback, an eco-evolutionary model system for studing immunogenetic adaptation and host-parasite coevolution in natural populations. This project builds on previous and ongoing work in the lab and uses experimental and computational tools to investigate individual T-cell repertoire diversity in response to different environmental and experimental conditions. The exact focus of the project can be tailored towards the experience and interest of the successful candidate. Apart from a strong interest in evolutionary questions, a biological understanding of the immune system and some previous experience in both wet lab work and bioinformatics is desirable.