Thomas Bosch

January 12, 2022

Please refer to and contact Thomas <> for further information on the project.

Functionality of microbial biogeography in health and disease: an evolutionary  informed approach

Here we want to investigate the spatial pattern of the microbial community and the underlying
mechanisms using the Hydra model. The project provides a unique contribution to understanding
symbiotic interactions in space and time. It aims to progress from the descriptive nature of
localization technologies to provide spatial, quantitative, and mechanistic insights into symbiotic
partnerships in vivo. Specifically we want to a) visualize the main bacterial colonizer of Hydra in a
temporal and spatial resolution; b) manipulate specific traits (such as mobility, biofilm formation,
quorum sensing etc.) of colonizing bacteria and c) investigate the effect of a changed spatial
distribution on the fitness of the host.


Bosch TCG and McFall-Ngai M (2021) Animal development in the microbial world: Re-thinking the
conceptual framework. Academic Press, 2021.;

McFall-Ngai M and Bosch TCG (2021) Animal development in the microbial world: The power of
experimental model systems. Current Topics in Developmental Biology. Academic Press 2021. ISSN

Donaldson, G., Lee, S. & Mazmanian, S. Gut biogeography of the bacterial microbiota. Nat Rev
Microbiol 14, 20–32 (2016).

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