Dr. Tobias L. Lenz
Dr. Tobias L. Lenz
Research Group Leader

Phone: + 49 4522 763-228
Fax: +49 4522 763-310
Room: Schlösschen

Selected recent publications

Chowell D, Krishna C, Pierini F, Makarov V, Rizvi NA, Kuo F, Morris LGT, Riaz N, Lenz TL* & Chan TA*

Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy

* equal contribution

Arora J, McLaren PJ, Chaturvedi N, Carrington M, Fellay J & Lenz TL

HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. 

Pierini F Lenz TL

Divergent allele advantage at human MHC genes: signatures of past and ongoing selection

Emmy Noether Group Evolutionary Immunogenomics (Lenz)

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Emmy Noether Group Evolutionary Immunogenomics

The coevolution between hosts and parasites is increasingly being recognized as one of the major drivers for the evolution of genetic diversity. We are interested in the evolutionary forces and constraints that shape the functional diversity of the vertebrate immune system, from the sequence level to genomic organisation and protein structure. Our research is strongly based on computational analysis of genomic and epidemiological data from human populations, but includes also molecular and experimental approaches using the three-spined stickleback and other model species. Current projects range from the genomic organisation of the major histocompatibility complex (MHC) in both sticklebacks and humans to immunogenetic selection in human populations and an evolutionary perspective on the association between human leukocyte antigen (HLA) diversity and autoimmunity as well as cancer.

Our research group is supported by the Emmy Noether Programme of the German Research Foundation (DFG).

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