Johanna Klughammer: "Reference genome independent DNA methylation analysis. Mapping genome-wide DNA methylation patterns across the species tree"
- Datum: 12.01.2018
- Uhrzeit: 12:00 - 13:00
- Vortragender: Johanna Klughammer vom CeMM, Vienna, Austria
- Mehr Informationen hier: http://www.medical-epigenomics.org/meg/index.php?option=com_content&view=article&id=93&catid=82&Itemid=489
- Ort: MPI Plön
- Raum: Hörsaal
- Gastgeber: Miriam Liedvogel
Abstract (auf Englisch)
The genome-wide study of DNA methylation at
cytosines is crucial for understanding fundamental biological
processes such as animal development, cellular differentiation,
and maintenance of cellular identity. Assessing DNA methylation in
a large variety of species and in wild populations is expected to
provide insights into evolutionary processes, environmental
adaptation, and mechanisms of epigenetic regulation.
To enable cost-efficient, genome-wide, high-resolution, and high-throughput analysis of DNA methylation in non-model organisms and in species that lack a high-quality reference genome, we developed an integrated experimental and computational approach for studying DNA methylation independent of a reference genome.
Empowered by this novel approach, we now investigate the evolutionary role of DNA methylation in the determination of cellular identity by mapping cell type specific genome-wide DNA methylation patterns in a large number of animal species across the species tree.