Victor de Lorenzo: Evolution as heterotic computing - How environmental bacteria conquest the chemical space
- Datum: 28.11.2018
- Uhrzeit: 14:00 - 15:00
- Vortragende(r): Victor de Lorenzo, Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
- Mehr Informationen über den Sprecher finden Sie hier: http://www.cnb.csic.es/index.php/es/investigacion/departamentos-de-investigacion/biologia-de-sistemas/microbiologia-medioambiental-molecular
- Ort: MPI Plön
- Raum: Hörsaal
- Gastgeber: Paul Rainey
Abstract (auf Englisch):
The
still-evolving 2,4-dinitrotoluene (DNT) pathway of Burkholderia
cepacia R34
has been studied as a case of
emergence of new metabolic capabilities in environmental
bacteria. The dnt route originated from
a precursor
naphthalene degradation pathway and the first enzyme (DNT
dioxygenase)
maintains significant activity towards its earlier substrate.
Both in vivo reactions and the
associated
regulatory system mediated by the DntR transcriptional factor
indicate that
reactive oxygen species (ROS) generated by the faulty (i.e.
uncoupled) reaction
of the precursor enzymes with DNT elicit genetic
diversification. This could in
turn ease the solution of the biochemical and physiological
problem. These
observations provide a view of evolution as a sort of
heterotic computing in
which the problem is embodied in the physicochemical frame of
the cell and the
exploration of the solution space is pushed by its endogenous
dynamics.