Daniel Falush: The landscape of coadaptation in Vibrio parahaemolyticus

  • Date: Nov 14, 2018
  • Time: 11:00 AM - 12:00 PM (Local Time Germany)
  • Speaker: Daniel Falush, University of Barth, UK
  • More information on the speaker can be found here: https://researchportal.bath.ac.uk/en/persons/daniel-falush
  • Location: MPI Plön
  • Room: Lecture hall
  • Host: Paul Rainey


We exploit the nearly panmictic population structure of the gastric pathogen Vibrio parahaemolyticus to perform a genome-wide screen for coadapted genetic elements. The great majority of interactions that we detect are between accessory genes, many involved in carbohydrate transport and metabolism. The most complex co-adaptations we identify include hundreds of core genome SNPs and accessory genome elements and involve genes encoding lateral flagella and cell wall biogenesis, implying that several strategies have evolved for colonizing surfaces. Our results provide evidence that, as in human relationships, coadaptation involves progressively increasing levels of commitment, with the most involved interactions becoming irreversible and presaging speciation.

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