Search results

Degenhardt, F.; Mayr, G.; Wendorff, M.; Boucher, G.; Ellinghaus, E.; Ellinghaus, D.; ElAbd, H.; Rosati, E.; Hübenthal, M.; Juzenas, S. et al.; Abedian, S.; Vahedi, H.; BK, T.; Yang, S.-K.; Ye, B. D.; Cheon, J. H.; Datta, L. W.; Daryani, N. E.; Ellul, P.; Esaki, M.; Fuyuno, Y.; McGovern, D. P.; Haritunians, T.; Hong, M.; Juyal, G.; Jung, E. S.; Kubo, M.; Kugathasan, S.; Lenz, T.; Leslie, S.; Malekzadeh, R.; Midha, V.; Motyer, A.; Ng, S.; Okou, D.; Raychaudhuri, S.; Schembri, J.; Schreiber, S.; Song, K.; Sood, A.; Takahashi, A.; Torres, E.; Umeno, J.; Alizadeh, B.; Weersma, R.; Wong, S.; Yamazaki, K.; Karlsen, T.; Rioux, J.; Brant, S.; Franke, A.: Trans-ethnic analysis of the human leukocyte antigen region for ulcerative colitis reveals shared but also ethnicity-specific disease associations. Human Molecular Genetics, In press (2021)

El Abd, H.; Bromberg, Y.; Hoarfrost, A.; Lenz, T. L.; Franke, A.; Wendorff, M.: Amino acid encoding for deep learning applications. BMC Bioinformatics 21, 235 (2020)

Ellinghaus, D.; Degenhardt, F.; Bujanda, L.; Buti, M.; Albillos, A.; Invernizzi, P.; Fernández, J.; Prati, D.; Baselli, G.; Asselta, R. et al.; Grimsrud, M. M.; Milani, C.; Aziz, F.; Kässens, J.; May, S.; Wendorff, M.; Wienbrandt, L.; Uellendahl-Werth, F.; Zheng, T.; Yi, X.; de Pablo, R.; Chercoles, A. G.; Palom, A.; Garcia-Fernandez, A.-E.; Rodriguez-Frias, F.; Zanella, A.; Bandera, A.; Protti, A.; Aghemo, A.; Lleo, A.; Biondi, A.; Caballero-Garralda, A.; Gori, A.; Tanck, A.; Carreras Nolla, A.; Latiano, A.; Fracanzani, A. L.; Peschuck, A.; Julià, A.; Pesenti, A.; Voza, A.; Jiménez, D.; Mateos, B.; Nafria Jimenez, B.; Quereda, C.; Paccapelo, C.; Gassner, C.; Angelini, C.; Cea, C.; Solier, A.; Pestaña, D.; Muñiz-Diaz, E.; Sandoval, E.; Paraboschi, E. M.; Navas, E.; García Sánchez, F.; Ceriotti, F.; Martinelli-Boneschi, F.; Peyvandi, F.; Blasi, F.; Téllez, L.; Blanco-Grau, A.; Hemmrich-Stanisak, G.; Grasselli, G.; Costantino, G.; Cardamone, G.; Foti, G.; Aneli, S.; Kurihara, H.; ElAbd, H.; My, I.; Galván-Femenia, I.; Martín, J.; Erdmann, J.; Ferrusquía-Acosta, J.; Garcia-Etxebarria, K.; Izquierdo-Sanchez, L.; Bettini, L. R.; Sumoy, L.; Terranova, L.; Moreira, L.; Santoro, L.; Scudeller, L.; Mesonero, F.; Roade, L.; Rühlemann, M. C.; Schaefer, M.; Carrabba, M.; Riveiro-Barciela, M.; Basso, F.; E., M.; Valsecchi, M. G.; Hernandez-Tejero, M.; Acosta-Herrera, M.; D’Angiò, M.; Baldini, M.; Cazzaniga, M.; Schulzky, M.; Cecconi, M.; Wittig, M.; Ciccarelli, M.; Rodríguez-Gandía, M.; Bocciolone, M.; Miozzo, M.; Montano, N.; Braun, N.; Sacchi, N.; Martínez, N.; Özer, O.; Palmieri, O.; Faverio, P.; Preatoni, P.; Bonfanti, P.; Omodei, P.; Tentorio, P.; Castro, P.; Rodrigues, P. M.; Blandino Ortiz, A.; de Cid, R.; Ferrer, R.; Gualtierotti, R.; Nieto, R.; Goerg, S.; Badalamenti, S.; Marsal, S.; Matullo, G.; Pelusi, S.; Juzenas, S.; Aliberti, S.; Monzani, V.; Moreno, V.; Wesse, T.; Lenz, T. L.; Pumarola, T.; Rimoldi, V.; Bosari, S.; Albrecht, W.; Peter, W.; Romero-Gómez, M.; D’Amato, M.; Duga, S.; Banales, J. M.; Hov, J. R.; Folseraas, T.; Valenti, L.; Franke, A.; Karlsen, T. H.: Genomewide association study of severe Covid-19 with respiratory failure. The New England Journal of Medicine: NEJM / Publ. by the Massachusetts Medical Society 383, pp. 1522 - 1534 (2020)

Pierini, F.; Nutsua, M.; Böhme, L.; Özer, O.; Bonczarowska, J.; Susat, J.; Franke, A.; Nebel, A.; Krause-Kyora, B.; Lenz, T. L.: Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations. Scientific Reports 10, 7339 (2020)

Radwan, J.; Babik, W.; Kaufman, J.; Lenz, T. L.; Winternitz, J.: Advances in the evolutionary understanding of MHC polymorphism. Trends in Genetics 36 (4), pp. 298 - 311 (2020)

Sagonas, K.; Meyer, B. S.; Kaufmann, J.; Lenz, T. L.; Häsler, R.; Eizaguirre, C.: Experimental parasite infection causes genome-wide changes in DNA methylation. Molecular Biology and Evolution 37 (8), pp. 2287 - 2299 (2020)

Arora, J.; Pierini, F.; McLaren, P. J.; Carrington, M.; Fellay, J.; Lenz, T. L.: HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation. Molecular Biology and Evolution 37 (3), pp. 639 - 650 (2020)

Immel, A.; Pierini, F.; Rinne, C.; Meadows, J.; Barquera, R.; Szolek, A.; Susat, J.; Böhme, L.; Dose, J.; Bonczarowska, J. et al.; Drummer, C.; Fuchs, K.; Ellinghaus, D.; Kässens, J. C.; Furholt, M.; Kohlbacher, O.; Schade-Lindig, S.; Franke, A.; Krause, J.; Müller, J.; Lenz, T. L.; Nebel, A.; Krause-Kyora, B.: Genome-wide study of a Neolithic Wartberg grave community reveals distinct HLA variation and hunter-gatherer ancestry. Communications Biology, In press (2020)

Koneczny, I.; Yilmaz, V.; Lazaridis, K.; Tzartos, J.; Lenz, T. L.; Tzartos, S. J.; Tüzün, E.; Leypoldt, F.: Common denominators in the immunobiology of IgG4 autoimmune diseases: What do glomerulonephritis, pemphigus vulgaris, myasthenia gravis, thrombotic thrombocytopenic purpura and autoimmune encephalitis have in common? Frontiers in immunology, In press (2020)

Huang, Y.; Feulner, P. G. D.; Eizaguirre, C.; Lenz, T. L.; Bornberg-Bauer, E.; Milinski, M.; Reusch, T. B. H.; Chain, F. J. J.: Genome-wide genotype-expression relationships reveal both copy number and single nucleotide differentiation contribute to differential gene expression between stickleback ecotypes. Genome Biology and Evolution 11 (8), pp. 2344 - 2359 (2019)

Degenhardt, F.; Wendorff, M.; Wittig, M.; Ellinghaus, E.; Datta, L. W.; Schembri, J.; Ng, S. C.; Rosati, E.; Hübenthal, M.; Ellinghaus, D. et al.; Jung, E. S.; Lieb, W.; Abedian, S.; Malekzadeh, R.; Cheon, J. H.; Ellul, P.; Sood, A.; Midha, V.; Bk, T.; Wong, S. H.; Schreiber, S.; Yamazaki, K.; Kubo, M.; Boucher, G.; Rioux, J.; Lenz, T. L.; Brant, S. R.; Franke, A.: Construction and benchmarking of a multi-ethnic reference panel for the imputation of HLA class I and II alleles. Human Molecular Genetics 28 (12), pp. 2078 - 2092 (2019)

Arora, J.; McLaren, P. J.; Chaturvedi, N.; Carrington, M.; Fellay, J.; Lenz, T. L.: HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control. Proceedings of the National Academy of Sciences of the United States of America 116 (3), pp. 944 - 949 (2019)

Chowell, D.; Krishna, C.; Pierini, F.; Makarov, V.; Rizvi, N. A.; Kuo, F.; Morris, L. G. T.; Riaz, N.; Lenz, T. L.; Chan, T. A.: Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature Medicine 25 (11), pp. 1715 - 1720 (2019)

Hasan Ali, O.; Berner, F.; Bomze, D.; Fässler, M.; Diem, S.; Cozzio, A.; Jörger, M.; Früh, M.; Driessen, C.; Lenz, T. L. et al.; Flatz, L.: Human leukocyte antigen variation is associated with adverse events of checkpoint inhibitors. European Journal of Cancer 107, pp. 8 - 14 (2019)

Manczinger, M.; Boross, G.; Kemény, L.; Müller, V.; Lenz, T. L.; Papp, B.; Pál, C.: Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations. PLoS Biology 17 (1), e3000131 (2019)

Lenz, T. L.; Hafer, N.; Samonte, I. E.; Yeates, S. E.; Milinski, M.: Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes. Evolution 72 (11), pp. 2478 - 2490 (2018)

Pierini, F.; Lenz, T. L.: Divergent allele advantage at human MHC Genes: signatures of past and ongoing selection. Molecular Biology and Evolution 35 (9), pp. 2145 - 2158 (2018)

Lenz, T. L.: Adaptive value of novel MHC immune gene variants. Proceedings of the National Academy of Sciences of the United States of America 115 (7), pp. 1414 - 1416 (2018)

Krause-Kyora, B.; Nutsua, M.; Boehme, L.; Pierini, F.; Pedersen, D. D.; Kornell, S.-C.; Drichel, D.; Bonazzi, M.; Möbus, L.; Tarp, P. et al.; Susat, J.; Bosse, E.; Willburger, B.; Schmidt, A. H.; Sauter, J.; Franke, A.; Wittig, M.; Caliebe, A.; Nothnagel, M.; Schreiber, S.; Boldsen, J. L.; Lenz, T. L.; Nebel, A.: Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans. Nature Communications 9, 1569 (2018)

Calvignac-Spencer, S.; Lenz, T. L.: The one past health workshop: connecting ancient DNA and zoonosis research. Bioessays 39 (7), 1700075 (2017)