Seminar series on Mathematical Evolutionary Biology - Pleuni Pennings: The evolution of HIV drug resistance evolution from the 1980s until now
- Date: Nov 20, 2018
- Time: 11:00 AM - 12:00 PM (Local Time Germany)
- Speaker: Pleuni Pennings from the San Francisco State University, CA, USA
- For more information on Pleuni Pennings, please check: http://biology.sfsu.edu/people/pleuni-pennings
- Location: MPI Plön
- Room: Lecture hall
- Host: Linda Odenthal-Hesse & Chaitanya S. Gokhale
Abstract
Drug resistance evolution was a huge problem for HIV treatment from the late 80s all the way until a a few years ago. It is often suggested that
the way to prevent drug resistance evolution is to use at least three drugs
at the same time. I will use historical data to show that it is more
complicated. The initial three-drug therapies for HIV still allowed for
drug resistance evolution to happen. I will propose a hypothesis that can
explain why newer triple-drug therapies work much better – we believe that
it is related to spatial structure of drug and virus in the human body.