The inevitable density-dependent dispersal in viral populations and its role in viral evolution

The inevitable density-dependent dispersal in viral populations and its role in viral evolution

  • Datum: 01.06.2021
  • Uhrzeit: 10:00 - 11:00
  • Vortragende(r): Diana Fusco, University of Cambridge
  • Ort: virtuelle Plattform
  • Gastgeber: Elisa Brambilla/ Paul Rainey
The inevitable density-dependent dispersal in viral populations and its role in viral evolution

Reaction-diffusion waves have long been used to describe the growth and spread of populations undergoing a spatial range expansion. Such waves are generally classed as either pulled, where the dynamics are driven by the very tip of the front and stochastic fluctuations are high, or pushed, where cooperation in growth or dispersal results in a bulk-driven wave in which fluctuations are suppressed. These concepts have been well studied experimentally in populations where the cooperation leads to a density-dependent growth rate. By contrast, relatively little is known about experimental populations that exhibit a density-dependent dispersal rate.

Using bacteriophage T7 as a test organism, we present novel experimental measurements that demonstrate that the diffusion of phage T7, in a lawn of host E. coli, is hindered by steric interactions with host bacteria cells. The coupling between host density, phage dispersal and cell lysis caused by viral infection results in an effective density-dependent diffusion rate. Using a system of reaction-diffusion equations, we show that this effect can result in a transition from a pulled to pushed expansion, even if no explicit cooperativity is introduced in the system. Moreover, we find that a second, independent density-dependent effect on phage dispersal spontaneously emerges as a result of the viral incubation period, during which phage is trapped inside the host unable to disperse. Our results indicate both that bacteriophage can be used as a controllable laboratory population to investigate the impact of density-dependent dispersal on evolution, and that the genetic diversity and adaptability of expanding viral populations could be much greater than is currently assumed.

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